Hydrochloric Acid → HCID 67395263, compound

Participants

Reaction Steps

To a solution of 2-(3-ethylquinoxalin-2-yl)-5-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine (132 mg, 2.00 mmol) in chloroform (2.0 mL) was added 4N hydrogen chloride solution in 1,4-dioxane (0.5 mL). The resulting precipitate was collected and washed with diethyl ether to give 2-(3-ethylquinoxalin-2-yl)-5-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine dihydrochloride (the compound of Example 1.004 listed in the Table of Examples as described hereinafter). 1H-NMR (400 MHz, DMSO-d6): δ 1.31 (3H, t, J=7.4 Hz), 1.85-1.91 (4H, m), 2.04-2.06 (4H, m), 3.45 (2H, q, J=7.4 Hz), 3.65 (4H, m), 3.94 (2H, m), 4.12 (1H, m), 5.64 (1H, s), 6.86 (1H, s), 7.84-7.92 (2H, m), 8.10-8.15 (2H, m), 8.34 (1H, br-d, J=8.8 Hz).

Provenance & Evidence