Hydrazine hydrate (1:1) → HCID 178432188, compound

Participants

Reaction Steps

To a suspension of 3-(7-fluoro-3-methylquinoxalin-2-yl)-3-oxopropanenitrile (48.6 g, 212 mmol) in ethanol (530 mL) and acetic acid (53 mL) was added hydrazine hydrate (79%, 19.6 mL, 318 mmol). The reaction mixture was reflux for 5 h, and then concentrated in vacuo. The residue was triturated with water and diisopropyl ether subsequently to give 3-(7-fluoro-3-methylquinoxalin-2-yl)-1H-pyrazol-5-amine. MS (APCI): m/z 244 (M+H).

Provenance & Evidence