Monoethyl malonate → HCID 178472230, compound

Participants

Reaction Steps

To a suspension of 3-(7-fluoro-3-methylquinoxalin-2-yl)-1H-pyrazol-5-amine (45.7 g, 188 mmol) in pyridine (750 mL) was added ethyl hydrogen malonate (5.35 mL, 62.5 mmol) and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (54.0 g, 282 mmol) at 0° C. The reaction mixture was stirred at ambient temperature for 3 h, and then concentrated in vacuo. The residue was triturated with water, ethanol and acetone subsequently to give ethyl 3-{[3-(7-fluoro-3-methylquinoxalin-2-yl)-1H-pyrazol-5-yl]amino}-3-oxopropanoate. MS (APCI): m/z 358 (M+H).

Provenance & Evidence