Water → HCID 53374175, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1-{[5-chloro-2-(7-fluoro-3-methylquinoxalin-2-yl)pyrazolo[1,5-c]pyrimidin-7-yl]amino}-2-methylpropan-2-ol (170 mg, 0.424 mmol), (R)-3-fluoropyrrolidine hydrochloride (268 mg, 2.12 mmol), and 1,8-diazabicyclo[5.4.0]undec-7-ene (387 mg, 2.54 mmol) in N-methylpyrrolidinone (5.0 mL) was heated at 70° C. overnight. After being cooled to ambient temperature, the reaction mixture was diluted with ice-cooled water. The resulting precipitate was collected and washed with water to give 1-({2-(7-fluoro-3-methylquinoxalin-2-yl)-5-[(3R)-3-fluoropyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)-2-methylpropan-2-ol. MS (APCI): m/z 454 (M+H).

Provenance & Evidence