Hydrochloric Acid → HCID 53374175, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1-({2-(7-fluoro-3-methylquinoxalin-2-yl)-5-[(3R)-3-fluoropyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)-2-methylpropan-2-ol (213 mg, 0.470 mmol) in ethanol (3.0 mL) was added 2N aqueous hydrochloric acid (0.282 mL), and the mixture was heated at 80° C., and then ethanol (2.0 mL) and water (0.2 mL) was added. The mixture was slowly cooled to ambient temperature and then ethanol (2.0 mL) was added. The resulting precipitate was collected, and washed with diethyl ether to give 1-({2-(7-fluoro-3-methylquinoxalin-2-yl)-5-[(3R)-3-fluoropyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)-2-methylpropan-2-ol hydrochloride (the compound of Example 1.006 listed in the Table of Examples as described hereinafter). 1H-NMR (400 MHz, DMSO-d6): δ 1.24 (6H, s), 2.25-2.43 (2H, m), 3.10 (3H, s), 3.62-3.70 (2H, m), 3.80-4.01 (4H, m), 5.52-5.63 (1H, m), 5.71 (1H, s), 6.94 (1H, s), 7.81 (1H, ddd, J=9.1, 8.8, 2.7 Hz), 7.95 (1H, dd, J=9.6, 2.9 Hz), 7.99 (1H, br), 8.14 (1H, dd, J=9.1, 5.9 Hz).

Provenance & Evidence