Water → HCID 178432309, compound

Participants

Reaction Steps

A suspension of ethyl 3-{[3-(3-methyl-7,8-dihydro-6H-pyrano[2,3-b]pyrazin-2-yl)-1H-pyrazol-5-yl]amino}-3-oxopropanoate (293 mg, 0.848 mmol) and N,N-dimethylaminopyridine (518 mg, 4.24 mmol) in methanol (3 mL), tetrahydrofuran (3 mL), and water (3 mL) was heated for 8 h. After being cooled to ambient temperature, the reaction mixture was concentrated in vacuo. The residue was triturated with ethyl acetate to give 2-(3-methyl-7,8-dihydro-6H-pyrano[2,3-b]pyrazin-2-yl)pyrazolo[1,5-a]pyrimidine-5,7-diol. MS (APCI): m/z 300 (M+H).

Provenance & Evidence