反应详情

A mixture of 3-(3-methylquinoxalin-2-yl)-1H-pyrazol-5-amine (Example 1.001 (c)) (200 mg, 0.888 mmol), ethyl 3-cyclopropyl-3-oxopropanoate (416 mg, 2.66 mmol), and sodium methoxide (28% in methanol, 1.03 g, 5.34 mmol) in 2-methoxyethanol (2.0 mL) was refluxed for 10 h. After being cooled to ambient temperature, the reaction mixture was acidified to pH 3-4 with acetic acid. The mixture was diluted with water and the resulting precipitate was collected and washed with diisopropyl ether to give 5-cyclopropyl-2-(3-methylquinoxalin-2-yl)pyrazolo[1,5-a]pyrimidin-7-ol. MS (APCI): m/z 318 (M+H).

1. temperaturewas refluxed for 10 h
2. customthe resulting precipitate was collected
3. washwashed with diisopropyl ether