反应详情

To a suspension of ethyl 5-[(3-ethoxy-3-oxopropanoyl)amino]-1H-pyrazole-3-carboxylate (2.60 g, 9.66 mmol) in ethanol (50 mL) and water (50 mL) was added N,N-dimethylaminopyridine (3.54 g, 29.0 mmol) at room temperature. After being stirred for 22 h, the reaction mixture was concentrated in vacuo. The residue was triturated with ethyl acetate/ethanol to give ethyl 5,7-dihydroxypyrazolo[1,5-a]pyrimidine-2-carboxylate. MS (APCI): m/z 224 (M+H), 123 (M+H, DMAP).

1. concentrationthe reaction mixture was concentrated in vacuo
2. customThe residue was triturated with ethyl acetate/ethanol