Hydrochloric Acid → HCID 178432731, compound

Participants

Reaction Steps

A suspension of ethyl 3-{[3-(6-isobutyl-3-methylpyrazin-2-yl)-1H-pyrazol-5-yl]amino}-3-oxopropanoate (1.13 g, 3.29 mmol) and triethylamine (1.38 mL, 9.88 mmol) in methanol (9 mL), tetrahydrofuran (9 mL), and water (9 mL) was refluxed for 2 h. After being cooled to ambient temperature, the reaction mixture was acidified to pH 2 with 2N aqueous hydrochloric acid and concentrated in vacuo. The residue was triturated with water to give 2-(6-isobutyl-3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidine-5,7-diol. MS (APCI): m/z 300 (M+H).

Provenance & Evidence