HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic Acid → 1-{4-Fluoro-5-(2-fluoropyridin-3-yl)-1-[(5-fluoropyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl}-N-methylmethanamine succinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic Acid | HCID 1110 | — |
| Reactant | 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(5-fluoropyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl)-N-methylmethanamine | HCID 67177002 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-{4-Fluoro-5-(2-fluoropyridin-3-yl)-1-[(5-fluoropyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl}-N-methylmethanamine succinate | HCID 67177001 | 85.7% |
Reaction Steps
A solution of succinic acid (46 mg) in ethanol (4 mL) was added to 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-[(5-fluoropyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl)-N-methylmethanamine (150 mg), and the mixture was concentrated under reduced pressure. The residue was recrystallized from ethanol to give the title compound as a white solid (yield 167 mg, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969387B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-b3294cd9a825423db0497c762b2e93dc |
| Source note | uspto-grants-2015_03 |