反应详情

A solution of 2-chloro-5-fluoro-4-methylbenzoic acid (Preparation 1b, 51.57 g) dissolved in conc sulfuric acid (143 mL) was treated with potassium nitrate (32.4 g) portionwise over 10 min at 0° C. under nitrogen. The resulting mixture was allowed to warm to room temperature before stirring at 50° C. for 1 h. The reaction mixture was quenched with ice water and the precipitate was collected and dried in vacuo to afford the subtitle compound (65.5 g).

1. customThe reaction mixture was quenched with ice water
2. customthe precipitate was collected
3. customdried in vacuo