7-Methoxy-4-nitro-1-(propan-2-yl)-1H-indole → HCID 59551030, compound

HRID 869832Notes

Reaction equation

HRID 869832 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([N+:15]([O-])=O)[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]>CO.C(OCC)(=O)C.[Pd]>[CH:1]([N:4]1[C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[CH:6]=[CH:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 534141937-Methoxy-4-nitro-1-(propan-2-yl)-1H-indole

Product 1

HCID 59551030HCID 59551030, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

A solution of 1-isopropyl-7-methoxy-4-nitro-1H-indole (T) (1 eq) and palladium 10% on activated carbon (0.1 wt eq) in methanol/ethyl acetate (1:1) was shaken on a Parr hydrogenation apparatus under hydrogen for 1 hr. The reaction was then filtered through Celite and evaporated to dryness to produce the desired product.

Workup

  1. filtrationThe reaction was then filtered through Celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-d59361625f784e31af212313af4e47dc
Source dataset
uspto-grants-2015_03
Patent number
US08969396B2

Reaction notes

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