Cesium carbonate → HCID 18980136, compound

Participants

Reaction Conditions

Reaction Steps

An oven-dried flask was charged with cesium carbonate (2.28 g, 7 mmol, 1.4 eq), Pd(OAc)2 (79 mg, 0.35 mmol, 0.07 eq), and X-phos (238 mg, 0.5 mmol, 0.1 eq) under nitrogen. 2-bromo-1-methoxy-4-nitrobenzene (1.16 g, 5 mmol, 1 eq), N1, N2, N2-trimethylethane-1,2-diamine (613 mg, 6 mmol, 1.2 eq) and toluene (20 mL, 0.25 M) were added, and the mixture was heated to 100° C. with stirring overnight. The reaction mixture was cooled to room temperature and concentrated. The crude product was then purified by flash chromatography on silica gel to give N1-(2-methoxy-5-nitrophenyl)-N1, N2, N2-trimethylethane-1,2-diamine (2) (340 mg, 1.34 mmol, 27%).

Provenance & Evidence