1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(6'-methoxy-3-methyl-5'-nitro-2,3'-bipyridin-6-yl)cyclopropanecarboxamide → N-(5'-amino-6'-methoxy-3-methyl-2,3'-bipyridin-6-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide

Participants

Reaction Steps

To 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6′-methoxy-3-methyl-5′-nitro-2,3′-bipyridin-6-yl)cyclopropanecarboxamide (71 mg, 0.15 mmol) in methanol (10 mL) was added Pd/C (15 mg, 0.015 mmol) The reaction was stirred at room temperature under a balloon of hydrogen for one hour before being filtered and evaporated to yield the product (53 mg, 77%). ESI-MS m/z calc. 454.15. found 455.1 (M+1)+. Retention time 1.75 minutes.

Provenance & Evidence