Hydrochloric Acid → HCID 117640814, compound

Participants

Reaction Conditions

Reaction Steps

To N-(5′-amino-6′-methoxy-3-methyl-2,3′-bipyridin-6-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide (53 mg, 0.1166 mmol) in 1,4-dioxane (2 mL) was added 4M aq hydrochloric acid (0.5 mL, 2.0 mmol) and the reaction mixture was heated to 90° C. After one hour the reaction was quenched with triethlyamine (0.5 mL). The reaction mixture was evaporated to dryness and the residue was dissolved in N,N-dimethylformamide (2 mL) and purified by reverse phase HPLC. The fractions from the HPLC purification were neutralized with saturated sodium bicarbonate and extracted with ethyl acetate (3×10 mL). The organics were dried over sodium sulfate and evaporated to yield the product (26 mg, 48%). ESI-MS m/z calc. 440.4. found 441.3 (M+1)+. Retention time 1.39 minutes.

Provenance & Evidence