Trimethylsilyl iodide → HCID 71053057, compound

Participants

Reaction Steps

To 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5′-fluoro-2′-methoxy-3-methyl-2,3′-bipyridin-6-yl)cyclopropanecarboxamide (42 mg, 0.09 mmol) in chloroform (1 mL) was added iodotrimethylsilane (55 mg, 0.3 mmol). The reaction mixture was stirred at room temperature for three hours. At this point the reaction mixture was purified directly by silica gel chromatography (eluting with 0-100% ethyl acetate in hexanes) to yield the product (19 mg, 47%). ESI-MS m/z calc. 443.38. found 443.96 (M+1)+. Retention time 1.56 minutes.

Provenance & Evidence