Trimethylsilyl iodide → HCID 68737441, compound

Participants

Reaction Conditions

Reaction Steps

To a slurry of 1-(2,3-dihydrobenzofuran-6-yl)-N-(6′-methoxy-4-methyl-2,3′-bipyridin-6-yl)cyclopropanecarboxamide (20 mg, 0.049 mmol) in acetonitrilee (1.5 mL) was added TMS-I (28.4 μL, 0.19 mmol) and the mixture was stirred at 55° C. for 7 h. The reaction was diluted with methanol (1.0 mL) and stirred at room temperature for 2 h. The resulting mixture was concentrated under vacuum, and taken into ethyl acetate (10 mL). The organic solution was washed with sodium bisulphate (2×2 ml), water (2×3 mL), dried over sodium sulphate and concentrated under vacuum. The solid was stirred with methanol (1.0 mL) at 40° C. for 10 min and collected by filtration, washed with methanol (1.0 mL) and dried under vacuum to yield the product (8.0 mg, 41%). ESI-MS m/z calc. 387.4. found 388.2 (M+1)+. Retention time 1.44 minutes.

Provenance & Evidence