反应详情

温度

-78 °C

3,4-Dibromothiophene (15.5 g, 64.1 mmol) was added dropwise to a solution of n-BuLi (2.5M in hexane, 25.6 mL, 64.1 mmol) in Et2O (50 mL) at −78° C. After 1.5 h, 3-chlorobenzaldehyde (7.29 mL, 64.1 mmol) was added dropwise to the beige suspension. The resulting solution was stirred at −78° C. for 1 h and allowed to warm to 0° C. After 1 h, the reaction was quenched by the addition of 25% aq. NH4OAc. The aqueous layer was extracted with EtOAc and the combined organics were washed with water and brine, dried (Na2SO4) and concentrated to afford the desired product as a pale yellow oil. The crude product was used directly without further purification.

1. temperatureto warm to 0° C
2. waitAfter 1 h
3. customthe reaction was quenched by the addition of 25% aq. NH4OAc
4. extractionThe aqueous layer was extracted with EtOAc
5. washthe combined organics were washed with water and brine
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated