HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Chlorobenzyl)thiophene-3-carboxylic acid → methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Chlorobenzyl)thiophene-3-carboxylic acid | HCID 45140589 | — |
| Reactant | [(1S)-1-(4-methoxycarbonylphenyl)ethyl]azanium chloride | HCID 161770108 | — |
| Product | methyl 4-[(1S)-1-({[4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate | HCID 45140964 | — |
Reaction Steps
4-(3-Chlorobenzyl)thiophene-3-carboxylic acid from Example 3, Step 3 (380 mg, 1.50 mmol) was reacted with (1S)-1-[4-(methoxycarbonyl)phenyl]ethanaminium chloride from Example 1, Step 9 under conditions similar to Example 1, Step 10. After chromatography on silica gel (EtOAc/hexane 40:60 to 95:5), the desired product was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969394B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-7d892b080f54498bb28d9bb3c3524b15 |
| Source note | uspto-grants-2015_03 |