2,5-Dichloro-4-(3-chlorobenzyl)thiophene-3-carboxylic acid → methyl 4-[(1S)-1-({[2,5-dichloro-4-(3-chlorobenzyl)-3-thienyl]carbonyl}amino)ethyl]benzoate

Participants

Reaction Steps

2,5-Dichloro-4-(3-chlorobenzyl)thiophene-3-carboxylic acid from Example 6, Step 1 (1.90 g, 5.91 mmol) was reacted with (1S)-1-[4-(methoxycarbonyl)phenyl]ethanaminium chloride from Example 1, Step 9 under conditions similar to Example 1, Step 10. The crude product was purified by Combi Flash chromatography system (2-5% EtOAc/toluene in 20 min.) to afford the desired product as a white solid. MS (−APCI): m/z 480 (M−1)−.

Provenance & Evidence