Diethyl Ether → 2,5-dichloro-4-[(3-chlorophenyl)(tetrahydro-2H-pyran-2-yloxy)methyl]thiophene-3-carboxylic acid

Participants

Reaction Steps

2-[(4-Bromo-2,5-dichloro-3-thienyl)(3-chlorophenyl)methoxy]tetrahydro-2H-pyran from Example 8, Step 2 (334 mg, 0.731 mmol) was reacted under conditions similar to Example 1, Step 6 (Et2O was used as a solvent instead of THF; reaction was quenched with 25% aq. NH4OAc instead of 1N HCl). The crude was purified by chromatography on silica gel (50:50 EtOAc/hexane containing 0.25% AcOH) to afford the desired product as a white foam.

Provenance & Evidence