Hydrochloric Acid → 4-[(1S)-1-({[2,5-dichloro-4-(3-chlorobenzoyl)-3-thienyl]carbonyl}amino)ethyl]benzoic acid

Participants

Reaction Steps

Methyl 4-[(1S)-1-({[2,5-dichloro-4-(3-chlorobenzoyl)-3-thienyl]carbonyl}amino)ethyl]benzoate from Example 10, Step 1 (73.0 mg, 0.147 mmol) was reacted under conditions similar to Example 1, Step 11. The reaction mixture was neutralized with 25% aq. NH4OAc (instead of an acidification with 1N HCl). The crude was purified by chromatography on silica gel (35:65 EtOAc/hexane containing 0.25% AcOH) to afford the desired product as an off-white solid. MS (−APCI): m/z 480 (M−1)−.

Provenance & Evidence