Water → sodium 4-{(1S)-1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]ethyl}benzoate

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Reaction Steps

To a solution of 4-{(1S)-1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]ethyl}benzoic acid from Example 12 (1.70 g, 3.68 mmol) in a mixture of EtOH (50 mL), THF (15 mL) and water (15 mL) was added NaOH (1N in water, 3.68 mL, 3.68 mmol). After 10 min. the solution was concentrated to dryness and the residue was dried under high vacuum to afford the desired product as an off-white solid. MS (−APCI): m/z 460 (M−23)−.

Provenance & Evidence