4-(1-Aminocyclopropyl)benzonitrile → N-[1-(4-cyanophenyl)cyclopropyl]-2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxamide

関与物質

反応手順

2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid from Example 11, Step 4 (286 mg, 0.910 mmol) was reacted with 4-(1-aminocyclopropyl)benzonitrile from Example 14, Step 1 (144 mg, 0.910 mmol) under conditions similar to Example 1, Step 10. The crude product was purified by Combi Flash chromatography system (2-5% EtOAc/CHCl3 in 20 min.) to afford the desired product as a pale yellow solid.

情報源と証拠