2,5-Dimethyl-4-(4-(trifluoromethyl)benzyl)thiophene-3-carboxylic acid → HCID 45141387, Verbindung

HRID 870066Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 870066
[CH3:1][C:2]1[S:3][C:4]([CH3:21])=[C:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)[C:6]=1[C:7](O)=[O:8].[Cl-].[CH3:23][O:24][C:25]([C:27]1[CH:32]=[CH:31][C:30]([C:33]2([NH3+:36])[CH2:35][CH2:34]2)=[CH:29][CH:28]=1)=[O:26]>>[CH3:1][C:2]1[S:3][C:4]([CH3:21])=[C:5]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]([F:20])([F:18])[F:19])=[CH:15][CH:16]=2)[C:6]=1[C:7]([NH:36][C:33]1([C:30]2[CH:31]=[CH:32][C:27]([C:25]([O:24][CH3:23])=[O:26])=[CH:28][CH:29]=2)[CH2:35][CH2:34]1)=[O:8]

Komponenten

3

Edukt 2

HCID 451407862,5-Dimethyl-4-(4-(trifluoromethyl)benzyl)thiophene-3-carboxylic acidHCID 86634826HCID 86634826, Verbindung

Produkt 1

HCID 45141387HCID 45141387, Verbindung

Versuchsvorschrift

2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]thiophene-3-carboxylic acid from Example 11, Step 4 (275 mg, 0.87 mmol) was reacted with 1-[4-(methoxycarbonyl)phenyl]cyclopropanaminium chloride from Example 16, Step 2 (167 mg, 0.86 mmol) under conditions similar to Example 11, Step 5. The crude product was purified by Combi Flash chromatography system (2-5% EtOAc/CHCl3 in 20 min.) to afford the desired product as a white solid.

Aufarbeitung

  1. customThe crude product was purified by Combi Flash chromatography system (2-5% EtOAc/CHCl3 in 20 min.)

Quellen und Nachweise

ORD-Eintrag
ord-f98827a928394e23b5ae3aae2a628b43
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969394B2

Notizen zur Reaktion

Wird geladen…