Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-, methyl ester → MK-2894

HRID 870067ノート

反応式

HRID 870067 の反応式
[CH3:1][C:2]1[S:3][C:4]([CH3:34])=[C:5]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=2)[C:6]=1[C:7]([NH:9][C:10]1([C:13]2[CH:22]=[CH:21][C:16]([C:17]([O:19]C)=[O:18])=[CH:15][CH:14]=2)[CH2:12][CH2:11]1)=[O:8]>CCO.CCCCCC>[CH3:1][C:2]1[S:3][C:4]([CH3:34])=[C:5]([CH2:23][C:24]2[CH:25]=[CH:26][C:27]([C:30]([F:32])([F:31])[F:33])=[CH:28][CH:29]=2)[C:6]=1[C:7]([NH:9][C:10]1([C:13]2[CH:22]=[CH:21][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)[CH2:12][CH2:11]1)=[O:8]

参加物

3

反応物 1

HCID 45141387Benzoic acid, 4-[1-[[[2,5-dimethyl-4-[[4-(trifluoromethyl)phenyl]methyl]-3-thienyl]carbonyl]amino]cyclopropyl]-, methyl ester

生成物 1

HCID 24952929MK-2894

試薬・触媒・溶媒 1

HCID 21879635Ethanol hexane溶媒

実験手順

Methyl 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoate from Example 16, Step 3 (172 mg, 0.353 mmol) was reacted under conditions similar to Example 1, Step 11. The crude solid was swished in 10:90 EtOH/hexane and the suspension was filtered. The resulting solid was rinsed with 10:90 EtOH/hexane, then hexane and dried to afford the desired product as a white solid. MS (−ESI): m/z 472 (M−1)−.

後処理

  1. filtrationthe suspension was filtered
  2. washThe resulting solid was rinsed with 10:90 EtOH/hexane
  3. dry with materialhexane and dried

出典と根拠

ORDレコード
ord-c28424df4a444b76875230596e38db86
出典データセット
uspto-grants-2015_03
特許番号
US08969394B2

反応ノート

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