HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (E)-3-[1-(4-Dimethylamino-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Dimethylamino)benzene-1-sulfonyl chloride | HCID 12506943 | — |
| Reactant | tert-butyl (2E)-3-(1H-pyrrol-3-yl)prop-2-enoate | HCID 66646340 | — |
| Product | (E)-3-[1-(4-Dimethylamino-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester | HCID 66646108 | — |
Reaction Steps
Starting materials: sodium hydride 60% (0.031 g), (E)-3-(1H-pyrrol-3-yl)-acrylic acid tert-butyl ester (compound D1) (0.100 g), 4-dimethylamino-benzenesulfonyl chloride (0.145 g). Reaction conditions: 30° C., 45 min; −30° C., 2.5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969401B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-052a71d4ac234d529eeccd7865ed28d6 |
| Source note | uspto-grants-2015_03 |