huagongshe.com
HRID870091

反应详情

EQUATION

反应方程式

HRID 870091 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[Na+].[Na+]
HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

结构：OB(O)c1cccnc1
HCID2734378

3-Pyridinylboronic acid

C5H6BNO2

结构：CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(Br)cc2)c1
HCID66646304

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)/C=C/c1ccn(S(=O)(=O)c2ccc(-c3cccnc3)cc2)c1
HCID66646399

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Cl][Pd][Cl].c1ccc(P(c2ccccc2)c2ccccc2)cc1
催化剂HCID13169693

未命名化合物

结构：COCCOC
溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

0.18 g (E)-3-[1-(4-bromo-benzenesulfonyl)-1H-pyrrol-3-yl]-acrylic acid tert-butyl ester (compound D4) and 62 mg 3-pyridylboronic acid are dissolved in 10 ml DME. A catalytic amount of bis-(triphenylphosphin-palladium (II)-chloride and 0.6 ml of an aqueous solution of sodium carbonate are added and the mixture is heated to reflux temperature overnight. The title compound is isolated by means of chromatography.

WORKUP

后处理

  1. temperaturethe mixture is heated
  2. temperatureto reflux temperature overnight