反应详情

温度

60 °C

Into a 100-mL round-bottom flask, was placed a solution of isophthalic acid (10 g, 60.24 mmol, 1.00 equiv) in 98% H2SO4 (60 mL). This was followed by the addition of N-bromosuccinimide (12.80 g, 72.32 mmol, 1.20 equiv), in portions at 60° C. in 10 min. The resulting solution was stirred overnight at 60° C. in an oil bath. The reaction was cooled to room temperature and then quenched by the addition of water/ice. The solids were collected by filtration, and washed with 2×60 mL of hexane. The solid was dried in an oven under reduced pressure. The crude product was purified by re-crystallization from ethyl acetate to give 3 g (20%) of 5-bromoisophthalic acid as a white solid.

1. customInto a 100-mL round-bottom flask, was placed
2. temperatureThe reaction was cooled to room temperature
3. customquenched by the addition of water/ice
4. filtrationThe solids were collected by filtration
5. washwashed with 2×60 mL of hexane
6. customThe solid was dried in an oven under reduced pressure
7. customThe crude product was purified by re-crystallization from ethyl acetate