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HRID870306

反应详情

EQUATION

反应方程式

HRID 870306 的结构方程式

REACTANTS

反应物

4
结构：NCCN
HCID3301

Ethylenediamine

C2H8N2

结构：COc1ccc(S)cc1
HCID12765

Benzenethiol, p-methoxy-

C7H8OS

结构：CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CC(N)=O)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O
HCID5742645

未命名化合物

2 次

结构：[O-]B([O-])Oc1ccccc1
HCID19793864

未命名化合物

PRODUCTS

生成物

1
结构：CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O
HCID2826718

Caspofungin

C52H88N10O15

PROCEDURE

实验过程

According to WO2010008493A2, Pneumocandin B0 as the starting material reacts with 4-methoxy thiophenol, the resulting product is protected by phenyl borate, the amide group in Pneumocandin B0 is reduced to amine group under the condition of dehydration by 3 A molecular sieve, and then the resulting product reacts with ethylenediamine to obtain caspofungin.