Hydrochloric Acid → HCID 11596180, compound

Participants

Reaction Steps

N-[6-(4-Isopropyl-benzenesulfonylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-propionamide (0.19 g, 0.47 mmol) was dissolved in 10 mL of tetrahydrofuran (THF) and 3 mL (31.3 mmol) of a borane-THF complex was introduced dropwise over 20 min. The resulting mixture was stirred at reflux for 3 h. The solution was cooled, 3 mL of 2 N HCl was added slowly, and the mixture was stirred at 40° C. for 1 h. The cooled solution was quenched with water, then NaOH (2N) and extracted with ethyl acetate. The organic phase was dried over MgSO4, filtered, and the filtrate was evaporated in vacuo to give the product as a colorless oil (100 mg, 55%).

Provenance & Evidence