4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 86626020, compound

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Reaction Steps

0.792 g (3.065 mmol) of a 1:1 mixture trans-(7-amino-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-1-yl)-propan-1-one and trans-(8-amino-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinolin-1-yl)-propan-1-one were dissolved in 20 ml pyridine. At 0-4° C., 0.75 g of 4-trifluoromethyl-benzene sulfonylchloride (3.066 mmol) were added, and the reaction stirred for 2 h under cooling. Pyridine was evaporated and the residue partitioned between 20% aqueous citric acid and diethylether. The aqueous layer was extracted twice with diethylether, the combined organic phases washed with 20% aqueous citric acid, dried over magnesium sulfate, filtered, and the solvent evaporated under reduced pressure to yield 1.327 g of the product. MSD: 467.1 g/mol

Provenance & Evidence