HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Propan-2-yl)benzene-1-sulfonyl chloride → N-[7-(4-isopropylbenzenesulfonylamino)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl]-propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Propan-2-yl)benzene-1-sulfonyl chloride | HCID 2734882 | — |
| Reactant | N-(7-amino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl)propionamide | HCID 68912527 | — |
| Solvent | Pyridine methylene chloride | HCID 21875418 | — |
| Product | N-[7-(4-isopropylbenzenesulfonylamino)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl]-propionamide | HCID 68912533 | — |
Reaction Steps
Following the same procedure as described in example 31.5, a portion of crude N-(7-amino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl)-propionamide (100 mg, 0.45 mmol) in CH2Cl2/pyridine 9/1 (20 ml) was treated with 4-isopropylbenzenesulfonyl chloride (130 μl, 0.72 mmol). Purification by flash column chromatography (CH2Cl2:methanol, 97:3) gave the title compound (85 mg, 47% for steps 31.4 and this step) as a gum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969552B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-8151142672744d52a088a651fd3cd75b |
| Source note | uspto-grants-2015_03 |