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HRID870372

反应详情

EQUATION

反应方程式

HRID 870372 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](CF)c1ccc(S(=O)(=O)Cl)cc1
HCID53628600

未命名化合物

结构：CCC(=O)NC1COc2cc(N)cnc2C1
HCID68912527

未命名化合物

PRODUCTS

生成物

1
结构：CCC(=O)NC1COc2cc(NS(=O)(=O)c3ccc([C@H](C)CF)cc3)cnc2C1
HCID68916577

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl.c1ccncc1
溶剂HCID21875418

未命名化合物

PROCEDURE

实验过程

Following the same procedure as described in example 31.5, a portion of crude N-(7-amino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl)-propionamide (95 mg, 0.43 mmol) in CH2Cl2/pyridine 9/1 (10 ml) was treated with 4-((S)-2-fluoro-1-methyl-ethyl)benzenesulfonyl chloride (132 mg, 0.55 mmol). Purification by flash column chromatography (CH2Cl2:MeOH, 97:3) gave the title compound (100 mg, 55% for step 31.4 and this step) as a gum.

WORKUP

后处理

  1. customPurification by flash column chromatography (CH2Cl2:MeOH, 97:3)