HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane;tetrahydrofuran → 4-Isopropyl-N-(3-propylamino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane;tetrahydrofuran | HCID 2723981 | — |
| Reactant | N-[7-(4-isopropylbenzenesulfonylamino)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl]-propionamide | HCID 68912533 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Isopropyl-N-(3-propylamino-3,4-dihydro-2H-pyrano[3,2-b]pyridin-7-yl)benzenesulfonamide | HCID 11661074 | 61.1% |
Reaction Steps
Following the same procedure as described in example 34, N-[7-(4-isopropylbenzenesulfonylamino)-3,4-dihydro-2H-pyrano[3,2-b]pyridin-3-yl]-propionamide (85 mg, 0.21 mmol) in THF (10 ml) was treated with 1M BH3.THF (2.1 ml, 2.1 mmol). Purification of the crude product by flash column chromatography (CH2Cl2:methanol, 97:3) gave the title compound (50 mg, 61%) as a white amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969552B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4afc4b60c2964008a3c612d4bbc131ef |
| Source note | uspto-grants-2015_03 |