Sodium Carbonate → HCID 73053668, compound

Participants

Reaction Steps

To a solution of N-(4-((2-(N-acetylacetamido)-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (259 mg, 0.47 mmol) in CH3OH (20 mL) was added a solution of Na2CO3 (59.8 mg, 0.56 mmol) in H2O (1 mL). After stirring at rt for 15 minutes, the mixture was concentrated in vacuo and the residue was purified by a silica gel column chromatography (CH3OH/EtOAc (v/v)=1/50) to give the title compound as a beige solid (160 mg, 66.7%).

Provenance & Evidence