Water → HCID 73053628, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-chloro-4-((6-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)pyridin-3-yl)oxy)picolinamide (290 mg, 0.6 mmol) in EtOAc (4 mL), CH3CN (4 mL), and H2O (2 mL) was added PhI(OAc)2 (234 mg, 0.72 mmol). The reaction was stirred at 0° C. for 30 minutes, then warmed up to rt and continued to stir for 12 hours. The mixture was filtered through a CELITE® pad, which was washed with DCM (30 mL). The filtrate was washed with water (20 mL), then concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/CH3OH (v/v)=50/1) to give the title compound as a light beige solid (120 mg, 44.7%).

Provenance & Evidence