Acetyl chloride → HCID 73053653, compound

Participants

Reaction Steps

To a solution of N-(5-((2-amino-3-chloropyridin-4-yl)oxy)pyridin-2-yl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (60 mg, 0.13 mmol), and Et3N (26.3 mg, 0.26 mmol) in CH2Cl2 (1 mL) and THF (2 mL) was added acetyl chloride (20 mg, 0.26 mmol). The reaction was stirred at rt for 3 hours, then treated with saturated Na2CO3 aqueous solution (2 mL). The resulted mixture was continued to stir at rt for 5 minutes, then concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/CH3OH (v/v)=50/1) to give the title compound as a light beige solid (15 mg, 22.7%).

Provenance & Evidence