HCID 86684707, Verbindung → 3-((tert-Butyldimethylsilanyl)oxy)azetidine

HRID 870479Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 870479
[Si:1]([O:8][CH:9]1[CH2:12][N:11](C(OCC2C=CC=CC=2)=O)[CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>C(O)C.[C].[Pd]>[Si:1]([O:8][CH:9]1[CH2:12][NH:11][CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 86684707HCID 86684707, Verbindung

Produkt 1

HCID 574386563-((tert-Butyldimethylsilanyl)oxy)azetidineAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

Into a solution of benzyl 3-[(tert-butyldimethylsilyl)oxy]azetidine-1-carboxylate (4.2 g, 13.06 mmol, 1.00 equiv) in ethanol (15 mL) was added palladium carbon (1.3 g, 0.30 equiv) at 0° C. in water/ice bath. The resulting solution was stirred overnight at room temperature. The solids were filtered off. The resulting mixture was concentrated under vacuum to afford 2.2 g (90%) of 3-[(tert-butyldimethylsilyl)oxy]azetidine (50.4) as a light yellow liquid.

Aufarbeitung

  1. filtrationThe solids were filtered off
  2. concentrationThe resulting mixture was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-c644805dbb3b415984b7e68bfb4a7759
Quelldatensatz
uspto-grants-2015_03
Patentnummer
US08969557B2

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