Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Bromopropane | HCID 6358 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Methoxy-3-(3-morpholinopropoxy)benzonitrile | HCID 10356088 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 53399549 | HCID 53399549 | — |
Reaction Steps
8 g Potassium carbonate and 2.7 g 3-hydroxy-4-methoxybenzonitrile (for synthesis see Example 47) was dissolved in 25 mL dimethylformamide. 2.15 mL 2-Bromopropane was added and the mixture stirred at 85° C. for 3 h. The mixture was concentrated, diluted in ethyl acetate and washed with water (×2) and saturated sodium chloride solution, dried over magnesium sulfate and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969568B2 |
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| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-286bb61791114392a7005c654c548fae |
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| Source note | uspto-grants-2015_03 |
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