反应详情

温度

50 °C

Add portionwise hydrochloric acid (900 mL; 5M in water; 5.17 equiv; 4.50 mole; 1.08 kg) to a solution of tert-butyl 2-(indan-2-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate (319 g; 1.00 equiv; 870.48 mmoles) in tetrahydrofuran (1.5 L). Once the addition is complete, stir the solution at 50° C. for 1 h. Cool the mixture to 25° C. and then add 3 L methyltert-butyl ether and 1 L water. Allow the solution to stand at 20° C. for 16 h. Separate the phases and extract the aqueous phase with dichloromethane (2 L). Discard the organic extracts and adjust the aqueous phase to pH 10 using 4M sodium hydroxide. Extract with ethyl acetate (3×3 L), and wash the combined organic extracts with saturated sodium chloride (2 L). Dry over anhydrous sodium sulfate, filter and concentrate to dryness to give a red gel. Redissolve the substance in ethyl acetate (300 mL) and petroleum ether (200 mL) at 50° C., and allow for precipitation over 24 hours. Filter and dry to afford the title compound (85 g, 37%). MS (m/z): 267 (M+1).

1. additionOnce the addition
2. temperatureCool the mixture to 25° C.
3. waitto stand at 20° C. for 16 h
4. customSeparate the phases
5. extractionextract the aqueous phase with dichloromethane (2 L)
6. extractionExtract with ethyl acetate (3×3 L)
7. washwash the combined organic extracts with saturated sodium chloride (2 L)
8. dry with materialDry over anhydrous sodium sulfate
9. filtrationfilter
10. concentrationconcentrate to dryness
11. customto give a red gel
12. custompetroleum ether (200 mL) at 50° C., and allow for precipitation over 24 hours
13. filtrationFilter
14. customdry