Trifluoroacetic acid → HCID 178521319, compound

Participants

Reaction Steps

Add trifluoroacetic acid (3 mL) slowly to a 0° C. solution containing tert-butyl {2-[2-(2,3-dihydro-1H-inden-2-ylamino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-oxoethyl}[2-(1H-1,2,3-triazol-5-yl)ethyl]carbamate (0.15 g; 1.0 equiv; 0.297 mmoles) in dichloromethane (1 mL). Stir for 2 hours, then warm to ambient temperature and stir for 30 minutes. Concentrate the mixture and dissolve the residue in dichloromethane (20 mL). Add saturated sodium bicarbonate (20 mL), brine (20 mL), and water (50 mL), and extract with dichloromethane (6×20 mL). Dry the combined organic extracts over magnesium sulfate, filter, and concentrate to afford 1-[2-(2,3-dihydro-1H-inden-2-ylamino)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl]-2-{[2-(1H-1,2,3-triazol-5-yl)-ethyl]amino}ethanone (0.093 g; 77%) as a yellowish foam: MS (m/z): 405(M+1).

Provenance & Evidence