HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 870604Generated: October 25, 2026
Triethylamine → 1-[2-(indan-2-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-2-(pent-4-ynylamino)ethanone
https://huagongshe.com/reaction/870604
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pent-4-yn-1-amine | HCID 641001 | — |
| Reactant | 2-chloro-1-[2-(2,3-dihydro-1H-inden-2-ylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]ethanone | HCID 86726528 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-[2-(indan-2-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-2-(pent-4-ynylamino)ethanone | HCID 86726571 | 100% |
Reaction Steps
Add triethylamine (0.434 mL; 2.0 equiv; 3.12 mmoles) followed by 4-pentyn-1-amine (0.194 mL; 1.50 equiv; 2.34 mmoles) to a solution of 2-chloro-1-[2-(2,3-dihydro-1H-inden-2-ylamino)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl]ethanone (0.534 g; 1.0 equiv; 1.56 mmoles) in tetrahydrofuran (5.19 mL). Stir for 48 hours at 55° C. The solution was directly concentrated to afford 1-[2-(indan-2-ylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-2-(pent-4-ynylamino)ethanone (0.606 g; 100%): MS (m/z): 390(M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08969555B2 |
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| Source dataset | uspto-grants-2015_03 |
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| ORD ID | ord-6fad47a17cd54d89bf4e164bea2acd8b |
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| Source note | uspto-grants-2015_03 |
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