3-Phenylpropylamine → HCID 86696333, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-bromo-6-chloro-imidazo[1,2-b]pyridazine (232 mg, 1 mmol) and phenylpropyl amine (1 ml, 7 mmol) in n-PrOH (1 mL) was heated in a microwave at 150° C. for 20 min. Additional phenylpropyl amine (0.5 ml) was added and reaction mixture heated for additional 20 min. then 30 min. in a microwave. The reaction mixture was concentrated and the residue was subjected to ISCO (40 g column, DCM 3 min. then 0-10% MeOH in DCM over 30 min.) to gave the product (380 mg ˜90% pure and was used directly for next step).

Provenance & Evidence