Potassium Carbonate → HCID 86696334, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (3-bromo-imidazo[1,2-b]pyridazin-6-yl)-(3-phenyl-propyl)-amine (100 mg, 0.3 mmol), (4-aminomethylphenyl)boronic acid hydrochloride (67 mg, 0.36 mmol), K2CO3 (124 mg, 0.9 mmol) and dichlorobis(triphenylphosphine)palladium(II) (11 mg, 0.015 mmol) in MeCN/water (3.6 ml/0.9 ml) was heated in a microwave at 150° C. for 20 min. The reaction mixture was diluted with MeOH (2 ml) and filtered. The filtrate was subjected to preparative HPLC to give the titled compound as AcOH salt (29.9 mg). 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.93 (s, 3H) 1.99-2.09 (m, 2H) 2.70-2.80 (m, 2H) 3.41 (t, J=6.95 Hz, 2H) 4.14 (s, 2H) 6.74 (d, J=9.60 Hz, 1H) 7.15-7.29 (m, 5H) 7.53 (d, J=8.34 Hz, 2H) 7.64 (d, J=9.60 Hz, 1H) 7.80 (s, 1H) 8.24 (d, J=8.59 Hz, 2H).

Provenance & Evidence