Acetone → HCID 86696340, compound

Participants

Reaction Steps

Acetone [67-64-1] (2.0 mL, 43.5 mmol), then powdered, activated, 4 Angstrom molecular sieve were added to a solution of N1-(3-bromoimidazo[1,2-b]pyridazin-6-yl)propane-1,3-diamine (367.2 mg, 1.4 mmol) in methanol (4.8 mL). The reaction vessel was closed and the mixture allowed to rapidly stir, at ambient temperature, for 17 h then its content rapidly transferred into a stirring suspension of sodium borohydride [16940-66-2] (0.3 g, 6.9 mmol) in methanol (50 mL). After 1 h the mixture was gravity filtered and the filtrate evaporated. The crude product was then taken up in ethyl acetate, washed with brine, dried (MgSO4) and evaporated to provide 196.9 mg of yellow solid. LRMS (ESI) m/z 312.0/314.0 [(M+H)]+, calc'd for C12H18BrN5: 312.21.

Provenance & Evidence