HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Aminopropyl)-2-pyrrolidinone → 3-((3-Bromoimidazo[1,2-b]pyridazin-6-ylamino)-propyl)-pyrrolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Aminopropyl)-2-pyrrolidinone | HCID 82111 | — |
| Reactant | 3-Bromo-6-fluoroimidazo[1,2-b]pyridazine | HCID 86696318 | — |
| Reactant | N1-(3-bromoimidazo[1,2-b]pyridazin-6-yl)-N3-methyl-N3-phenylpropane-1,3-diamine | HCID 86696351 | — |
| Product | 3-((3-Bromoimidazo[1,2-b]pyridazin-6-ylamino)-propyl)-pyrrolidin-2-one | HCID 86696362 | 68% |
Reaction Steps
The 3-bromo-6-fluoroimidazo[1,2-b]pyridazine was alkylated with 1-(3-aminopropyl)pyrrolidin-2-one, under same reaction condition as used in the synthesis of N1-(3-bromoimidazo[1,2-b]pyridazin-6-yl)-N3-methyl-N3-phenylpropane-1,3-diamine example 5.6.29 to obtain 68% product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969565B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cdadcbf536bd4f64892f0bfced110d84 |
| Source note | uspto-grants-2015_03 |