HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Boronothiophene-2-carboxylic acid → 5-(6-((3-(2-Oxopyrrolidin-1-yl)propyl)amino)imidazo[1,2-b]pyridazin-3-yl)thiophene-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Boronothiophene-2-carboxylic acid | HCID 2779807 | — |
| Reactant | 1-(3-(3-Bromoimidazo[1,2-b]pyridazin-6-ylamino)propyl)pyrrolidin-2-one | HCID 68648159 | — |
| Product | 5-(6-((3-(2-Oxopyrrolidin-1-yl)propyl)amino)imidazo[1,2-b]pyridazin-3-yl)thiophene-2-carboxylic acid | HCID 86696364 | 64% |
Reaction Steps
The Suzuki coupling of 5-boronothiophene-2-carboxylic acid and 1-(3-((3-bromoimidazo[1,2-b]pyridazin-6-yl)amino)propyl)pyrrolidin-2-one using the procedure described in example 5.6.19 yielded 64% of the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08969565B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e1a63cf5c83c49deb344d5159ee5ce41 |
| Source note | uspto-grants-2015_03 |