Trifluoroacetic acid → HCID 86696365, compound

Participants

Reaction Steps

To 50 mg (0.094 mmol) of N-(2,4-dimethoxybenzyl)-5-(6-((3-(2-oxopyrrolidin-1-yl)propyl)amino)imidazo[1,2-b]pyridazin-3-yl)thiophene-2-carboxamide dissolved in 1 mL DCM was added 5 mL of TFA. The resulting solvent was stirred at rt for 0.5 hr and then concentrated. It was purified in the PREP HPLC to obtain 26 mg (72%) of the desired product. 1H NMR (400 MHz, METHANOL-d4) δ ppm 2.04 (quin, J=7.39 Hz, 4H) 2.33-2.41 (m, 2H) 3.45-3.60 (m, 6H) 6.76 (d, J=9.85 Hz, 1H) 7.64-7.72 (m, 2H) 7.75 (d, J=4.04 Hz, 1H) 7.94 (s, 1H); LRMS (ESI) m/e 385.0 [(M+H)+, calcd for C18H20N6O2S 384.0].

Provenance & Evidence