Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-(2-Methoxyphenoxy)ethyl amine | HCID 1713005 | — |
| Reactant | 3-Bromo-6-chloroimidazo(1,2-b)pyridazine | HCID 12872323 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86696389 | HCID 86696389 | 44.1% |
Reaction Steps
A mixture of 3-bromo-6-chloro-imidazo[1,2-b]pyridazine (232 mg, 1 mmol) and 2-(2-methoxy-phenoxy)-ethylamine (2 g, 12 mmol) was heated in a microwave at 160° C. for 30 min. The reaction mixture was subjected to ISCO (40 g column, DCM 3 min. then 0-10% MeOH in DCM over 30 min.) to gave the product (160 mg). LRMS (ESI) m/z 363 and 365.1 [(M+H)]+, calc'd for C15H15BrN4O2: 363.22.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08969565B2 |
|---|
| Source dataset | uspto-grants-2015_03 |
|---|
| ORD ID | ord-89274bc8e9a74c2cb97d904c013117d5 |
|---|
| Source note | uspto-grants-2015_03 |
|---|
